Prevention trials

Prevention trials in clinical research are specific types of clinical trials that focus on evaluating interventions or strategies aimed at preventing the development or occurrence of diseases, conditions, or health problems. These trials aim to identify preventive measures that can reduce the risk, incidence, or progression of specific health outcomes.


Prevention trials can be categorized into different types based on their objectives:

Primary Prevention Trials: These trials investigate interventions targeting individuals who have not yet developed the condition of interest. The goal is to prevent the initial occurrence or onset of a disease or health problem. Examples include trials evaluating vaccines, lifestyle interventions, or medications for preventing conditions like heart disease, cancer, or infectious diseases.

Secondary Prevention Trials: These trials involve individuals who are at high risk or have early signs of a disease or condition but have not yet experienced significant symptoms or complications. The interventions aim to prevent the progression or complications of the condition. Examples include trials evaluating medications or lifestyle modifications to prevent the progression of pre-diabetes to diabetes or interventions to prevent the recurrence of certain cancers.

Tertiary Prevention Trials: These trials focus on individuals who have already been diagnosed with a disease or condition and aim to prevent further complications or relapses. The interventions in these trials are designed to minimize the impact of the disease and improve the quality of life. Examples include trials evaluating rehabilitation programs or supportive care strategies for individuals with chronic conditions or disabilities.

Pharmacokinetics, measuring the effect of dose on rates of absorption and excretion of drugs from various body compartments;

Pharmacodynamics, measuring the intended or unintended effects of dose on physiologic measures;

Toxicology, measuring the effect of dose on histopathologic lesions in major organ systems;

Reproductive and embryologic effects as a function of dose.

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